Archive
Past Journal Club Presentations
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2020-03-25 - Wilson Poon (University of Toronto) - Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach
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2020-04-08 - Shrey Sindhwani (University of Toronto) - Targeted Delivery of RNAi Therapeutics with Endogenous and Exogenous Ligand-Based Mechanisms
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2020-04-20 - Preethi Korangath (Johns Hopkins University) - Nanoparticle Interactions with Immune Cells Dominate Tumor Retention and Induce T Cell-Mediated Tumor Suppression in Models of Breast Cancer
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2020-05-06 - Qiang Cheng (UT Southwestern) - Selective Organ Targeting (SORT) Nanoparticles for Tissue-Specific mRNA Delivery and CRISPR-Cas Gene Editing
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2020-05-20 - Laura Maiorino (MIT) - A STING-activating Nanovaccine for Cancer Immunotherapy
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2020-06-03 - Alexandros Marios Sofias (RWTH Aachen University) - Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking
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2020-06-18 - Roy Pattipeiluhu (Leiden University) - Unbiased Identification of the Liposome Protein Corona using Photoaffinity-based Chemoproteomics
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2020-07-02 - Yi-Nan Zhang (Univeristy of Toronto) - Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity
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2020-07-15 - Irene de Lazaro (Harvard University) - Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy
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2020-07-29 - Carly Pellow (Univeristy of Toronto) - Simultaneous Intravital Optical and Acoustic Monitoring of Ultrasound-Triggered Nanobubble Generation and Extravasation
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2020-08-12 - George Ueda (University of Washington) - Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens
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2020-09-12 - Ben Ouyang (University of Toronto) - The Dose Threshold for Nanoparticle Tumour Delivery
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2020-09-26 - Anvay Ukidve (Sanofi) - Erythrocyte-Driven Immuniation via Biomimicry of Their Natural Antigen-Presenting Function
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2020-10-10 - Gabriela Arias Alpizar (Leiden University) - Light-Triggered Switching of Liposome Surface Charge Directs Delivery of Membrane Impermeable Payloads In Vivo
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2020-10-24 - Jayesh Kulkarni (University of British Columbia) - On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
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2020-11-07 - Danielle Valcourt (Leidos Inc.) - Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine
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2020-11-21 - Lisa Volpatti (University of Chicago) - Glucose-Responsive Nanoparticles for Rapid and Extended Self-Regulated Insulin Delivery
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2020-12-05 - Nathan Donahue (University of Oklahoma) - High-Throughput Quantitation of Inorganic Nanoparticle Biodistribution at the Single-Cell Level Using Mass Cytometry
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2021-01-16 - Kalina Paunovska (Georgia Institute of Techology) - Increased PIP3 Activity Blocks Nanoparticle mRNA Delivery
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2021-01-30 - Maria Poley (Technion Israel Institute of Technology) - Chemotherapeutic Nanoparticles Accumulate in the Female Reproductive System During Ovulation Affecting Fertility and Anticancer Activity
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2021-02-13 - Bill Ling (California Institute of Technology) - Biomolecular Ultrasound Imaging of Phagolysosomal Function
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2021-02-27 - Eric Tawagi (University of Toronto) - Controlling the Biological Fate of Micellar Nanoparticles: Balancing Stealth and Targeting
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2021-03-13 - Miles Miller (Harvard Medical School) - Tumour-Associated Macrophages Act as a Slow-Release Reservoir of Nano-Therapeutic Pt(IV) Pro-Drug
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2021-03-27 - Marta Overchuk (University of Toronto) - Subtherapeutic Photodynamic Treatment Facilities Tumour Nanomedicine Delivery and Overcomes Desmoplasia
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2021-04-10 - Rebecca Pinals (UC Berkeley) - Quantiative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments
- 2021-04-24 - Alexandra Vaideanu (University College London) - On the Shuttling Across the Blood-Brain Barrier via Tubules Formation: Mechanism and Cargo Avidity Bias
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2021-05-15 - Alexander Cohen (California Institute of Techology) - Mosaic Nanoparticles Elicit Cross-Reactive Immune Responses to Zoonotic Coronaviruses in Mice
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2021-05-29 - Yin Bohan (The Hong Kong Polytechic University) & Ho Lok Wai (Cola) (Chinese University of Hong Kong) - Sub-10 nm Substrate Roughness Promotes the Cellular Uptake of Nanoparticles by Upregulating Endocytosis-Related Genes
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2021-06-12 - Shrusti Patel (Vanderbilt University) - Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid Nanocarriers
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2021-06-26 - Daniel Rosenblum (New York University) & Anna Gutkin (Tel Aviv University) - CRISPR-Cas9 Genome Editing using Targeted Lipid Nanoparticles for Cancer Therapy
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2021-07-10 - Bram Priem & Mandy van Leent (Icahn School of Medicine at Mount Sinai) - Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition
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2021-07-24 - Yuwei (Johnny) Zhang (University of Toronto) - An Analysis of the Binding Function and Structure of the Protein Corona
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2021-08-07 - Akira Nishio (Osaka University) - Clearance of PEGylated Interferon by Kupffer Cells Limits NK Cells Activation and Therapy Response of Patients with HBV Infection
- 2021-08-21 - Xiao Huang (UC San Francisco) - DNA Scaffolds Enable Efficient and Tunable Functionalization of Biomaterials for Immune Cell Modulation
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2021-09-25 - Suxin Li (UT Southwestern Medical Center) - Prolonged Activation of Innate Immune Pathways by a Polyvalent STING Agonist
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2021-10-02 - Tanja Rothgangl (University of Zurich) - In Vivo Adenine Base Editing of PCSK9 in Macaques Reduces LDL Cholesterol Levels
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2021-10-16 - Krzysztof Kucharz (University of Copenhagen) - Post-Capillary Venules are the Key Locus for Transcytosis-Mediated Brain Delivery of Therapeutic Nanoparticles
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2021-11-01 - Natalie Boehnke & Joelle Straehla (Massachusetts Institute of Technology) - Massively Parallel Pooled Screening Reveals Genomic Determinants of Nanoparticle-Cell Interactions
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2021-11-13 - Benjamin Kingston (University of Toronto) - Specific Endothelial Cells Govern Nanoparticle Entry Into Solid Tumors
- 2021-11-27 - Kasturi Chakraborty (University of Chicago) - Tissue Specific Targeting of DNA Nanodevices in a Multicellular Living Organism
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2022-01-15 - Steve Roffler (Academia Sinica) - Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-PEG Antibodies
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2022-01-29 - Kai Liu (AstraZeneca) - An Obesity Model and Corona Multiomics Analysis Reveal High-Density Lipoprotein Effects on Lipid Nanoparticle Function
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2022-02-12 - Samagya Banskota (Harvard University) - Engineering Virus-LIke Particles for Efficient In Vivo Delivery of Therapeutic Proteins
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2022-02-26 - Huan Zhang (Jinan University) - Nanoparticle Cellular Internalization is not Required for RNA Delivery to Mature Plant Leaves
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2022-03-12 - Yajuan Zou (Okayama University) - Polyglycerol Grafting Shields Nanoparticles from Protein Corona Formation to Avoid Kupffer Cell Uptake
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2022-03-26 - Oscar Marcos-Contreras (University of Pennsylvania) - Selective Targeting of Nanomedicine to Inflamed Cerebral Vasculature to Enhance the Blood-Brain Barrier
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2022-04-09 - Shoaib Iqbal (University of Delaware) - Critical Evaluation of Different Lysosomal Labeling Methods Used to Analyze RNA Nanocarrier Trafficking in Cells
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2022-04-23 - Dominik Witzigmann (NanoVation Therapeutics) - Optimization-by-Design of Hepatotropic Lipid Nanoparticles Targeting the Sodium Taurocholate Cotransporting Polypeptide
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2022-05-07 - Daniel Tylawsky (Weill Cornell Medicine & Sloan-Kettering Institute) - P-Selectin Targeting Stimulates Caveolin-1-Mediated Endothelial Transcytosis in Medulloblastoma
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2022-05-21 - Sean Dilliard (UT Southwestern Medical Center) - On the Mechanism of Tissue-Specfiic mRNA Delivery by Selective Organ Targeting Nanoparticles
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2022-06-04 - Jilian Melamed (Carnegie Mellon University) - LIpid Nanoparticle Chemistry Determines How Nucleoside Base Modifications Alter mRNA Delivery
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2023-03-30 - Jie Zhuang (Nankai University) - Machine-Learning-Assisted Single-Vessel Analysis of Nanoparticle Permeability in Tumour Vasculatures
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2023-04-26 - Grayson Tilstra & Julien Couture-Senécal (University of Toronto) - Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery
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2023-05-24 - Ran Li (Genentech) - Therapeutically Reprogrammed Nutrient Signalling Enhances Nanoparticulate Albumin Bound Drug Uptake Efficacy in KRAS-mutant Cancer
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2023-06-27 - Zachary Lin (University of Toronto) - Macrophages Actively Transport Nanoparticles in Tumors After Extravasation
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2023-07-11 - Ernest Moles (UNSW Sydney) - Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia
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2023-07-18 - Jilian Melamed (University of Pennsylvania) - Ionizable lipid nanoparticles deliver mRNA to pancreatic beta cells via macrophage-mediated gene transfer
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2023-08-15 - Mchelle Teplensky (Boston University) - Multi-antigen spherical nucleic acid cancer vaccines